A groundbreaking study has discovered that cell membrane damage can lead to cellular senescence, a state associated with aging and disease. This adds a third possible outcome to the previously understood consequences of cell damage—recovery or death. The research highlights the impact of moderate membrane damage on cell fate and opens new paths for promoting healthy aging by understanding and manipulating the underlying mechanisms of cellular senescence. Credit: SciTechDaily.com Kintsugi, the traditional Japanese art of repairing broken pottery by mending cracks with lacquer and gold. Kintsugi visibly incorporates the history of an object into its new form. In this analogy, cell membrane damaged is repaired, however, rather than restoring the cell to its original form, the new cellular nature is irreversibly changed and the cells behave differently in our body. Credit: Amy Cao, Salk Institute
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