Scientists have developed a non-invasive brain stimulation method, Patterned Low-Intensity Low-Frequency Ultrasound (LILFUS), which can precisely modulate brain function and induce lasting changes. This breakthrough overcomes the limitations of traditional stimulation methods and shows potential for treating neurological disorders, improving motor skills, and possibly aiding in rehabilitation therapies. The research opens new avenues for using ultrasound in brain therapy, with implications for treating a wide range of conditions. Credit: SciTechDaily.com In this experiment, ultrasound protocols comprising two distinct stimulation patterns by combining Low-Intensity Low-Frequency (LILF) 30Hz and 5Hz ultrasound were used. The first pattern, known as intermittent TBUS, featured intermittent stimulation with 2 seconds of stimulation followed by 8 seconds of rest. The second pattern, termed continuous TBUS, involved 40 seconds of uninterrupted stimulation. Throughout the stimulation, brainwaves were monitored by analyzing the phase-amplitude coupling between theta and gamma waves, which are two primary types of brainwaves. The accompanying graph illustrates these observed changes. Credit: Institute for Basic Science This figure summarizes the outcomes following ultrasound stimulation. Low-intensity brainwave-like pattern ultrasound stimulation sequentially stimulates TRPA1 in astrocytes, leading to BEST1-dependent neurotransmitter secretion. This, in turn, stimulates adjacent neurons, inducing neural plasticity in the neurons. This process briefly describes how changes in cognitive functions associated with pattern-dependent memory and learning, as well as changes in behavioral aspects, become evident. Credit: Institute for Basic Science
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201 ngày
