A new study by the Salk Institute presents a groundbreaking non-hormonal and reversible male contraceptive method using HDAC inhibitors to block sperm production without affecting libido. This method, targeting the regulation of gene expression in sperm production, promises fewer side effects and fully reversible fertility, indicating a significant advance in the development of male contraceptives. Sperm, pictured inside the cross-sectioned tube of the epididymis, were not generated while mice took the HDAC inhibitor drug (top right), but after 60 days off the drug, spermatogenesis was recovered (bottom right). The left column shows sperm at the same time points in a mouse that did not receive the drug. Credit: Salk Institute From left: Ruth Yu, Suk-Hyun Hong, Ronald Evans, Annette Atkins, and Michael Downes. Credit: Salk Institute
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