New research reveals that stress promotes cancer metastasis by causing neutrophils to form structures that facilitate the disease’s spread. This finding highlights the importance of incorporating stress reduction into cancer treatment and suggests new avenues for preventing cancer metastasis through targeted therapies. For a recent CSHL Cancer Center study, Adjunct Professor Mikala Egeblad (now a Bloomberg Distinguished Professor with Johns Hopkins University) and postdoc Xue-Yan He (now Assistant Professor of Cell Biology & Physiology at Washington University School of Medicine in St. Louis) teamed with CSHL Professor Linda Van Aelst. Above: lung cancer metastasis in a mouse that underwent experiments designed to simulate the stress that cancer patients experience. Credit: Egeblad lab/Cold Spring Harbor Laboratory Cancer spread faster and more furiously in stressed mice (middle column) than in a control group (left column). By comparison, cancer cells in stressed mice treated with an enzyme called DNase I (right column) were largely non-proliferating, and the treatment caused a significant reduction in stress-induced metastasis. Credit: Egeblad lab/Cold Spring Harbor Laboratory
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